Analyzing cells at the molecular level while maintaining the spatial context is key to navigating the complexity of biological systems and understanding human disease. A thorough understanding of where genes are expressed, and their surrounding environment (‘microenvironment’) has the promise to guide the development of novel treatments.
SpatialPlex services can precisely characterize constituent tumor cell populations, infiltrating lymphocytes and stromal elements while preserving spatial positioning within tissue architecture.
SpatialPlex utilizes highly multiplexed profiling of protein and RNA in tissue using GeoMx® from Nanostring, and interrogation of rare or single cells with RNAscope®ISH, from ACD Bio. We continue to build out our spatial genomics offerings with new services.
SpatialPlex Services can:
Our spatial biology experts are focused upon your success and can aid in designing experiments, selecting tissue and ROIs of interest, and interpreting results
Profile immune contexture of tumor microenvironment
Identify Immune/Stromal GC Dark Zone/Light Zone Signature
Assess Inter- and Intratumor Variation of Metastases
Immune Monitoring Following Transplantation
High plex characterization of B- and T-cells
Immune Marker Discovery with Prognostic and Predictive Potential
Monitoring Therapeutic Response and Resistance
The tumor microenvironment, comprising multiple cellular and molecular factors, plays a critical role in tumorigenesis, metastasis, and drug resistance. Thus, the deconvolution of the tumor microenvironment is fundamental for the progress of cancer research and treatment success.
While immunohistochemistry (IHC) plays a central role in the clinical diagnosis and prognosis of cancer, as well as the selection of patients for targeted therapies, the magnitude of the complex network of markers is lacking due to the limitation in multiplexing and quantitative ability.
Likewise, the clinical introduction of next-generation sequencing has made it possible to match mutational profiles to specific targeted therapies, however improving response rates to immunotherapy will similarly require a deep understanding of the immune microenvironment and the spatial context of each component in a patient-specific way.