Anatomic Pathology, Flow Cytometry, & Cytogenetic Solutions

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Paving the Way to Personalized Treatment

Built on the foundation of world-class scientific knowledge and a historical legacy in cytogenetics and anatomic pathology, Pharma Solutions is a leader in the field of personalized medicine, offering a comprehensive suite of cytogenetic and molecular pathology tests. As the list of biomarkers expands as the field of personalized medicine progresses, we strive to continue to add to our menu of clinically-validated diagnostic tests.  At Pharma Solutions, we provide a wide range of fit-for-purpose services, specifically tailored to your overall scientific and clinical objectives, including optimizing and validating unique markers relevant to your clinical program.

Anatomic Pathology

Immunohistochemistry (IHC)

Pharma Solutions provides full IHC capabilities accommodating a variety of analyses utilizing various platforms. Its state-of-the-art IHC laboratory is equipped with modern automation and advanced capabilities, including digital pathology. Pharma Solutions has implemented lean workflow processes that track sample custody at various steps in the IHC lab and provides metrics on performance in real-time. Pharma Solutions’ IHC portfolio includes a full range of FDA-cleared IHC-based complementary and companion diagnostics (CDx) in support of cutting edge immuno-oncology drugs, as well as a comprehensive library of over 200 antibodies for various IHC markers in oncology.

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In Situ Hybridization (ISH) and Other Special Stains

In addition to a full immunohistochemical library of antibodies, we offer both ISH and special staining with core expertise in hematological tumors and common solid tumors. 

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State-of-the-Art Anatomic Pathology Laboratory with Significant Automation

  • Platform-agnostic: Ventana and Dako stainers
  • Digital Pathology
  • Lean workflow (Vantage) system that keeps track of sample custody at various steps in the lab and provides metrics on performance in real-time.
  • Leica Biosystems Aperio AT2 scanner, iScan Coreo scanner with Virtuoso image analysis software
  • BioView scanner and image analysis system

Flow Cytometry

Pharma Solutions provides unique flow cytometry (FC) services implemented with comprehensive and customizable solutions. Our staff is highly experienced in custom assay development and validation utilizing its broad scientific/technical expertise and our comprehensive FC platforms. We also offer a broad menu of clinically validated CLIA- and NYS-approved panels covering multiple disease states. Our FC program includes high-sensitivity minimal residual disease (MRD) monitoring. Some of our MRD panels have established sensitivity at 0.01% and have CLIA and NYS approval. Our industry-leading immuno-oncology panel, Complete::IO, is the most comprehensive FC- based biomarker panel in the industry.

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Cytogenetics and Fluorescence in Situ Hybridization (FISH)

Pharma Solutions offers a complete cytogenetics laboratory with karyotyping and FISH capabilities. It is staffed with highly experienced professionals, with an average of 15 years of experience in cytogenetics. Pharma Solutions’ state-of-the-art cytogenetics laboratory is equipped with automated FISH and metaphase capture stations. 

Our staff is highly experienced in various cytogenetic techniques required for handling a variety of specimen types including bone marrow (BM), peripheral blood (PB), lymph node, cerebrospinal fluid, pleural effusion, short-term cultures, etc. Our laboratory is equipped to perform FISH analysis for 50+ probes on hematological malignancies. We are one of the elite centers for performing CD138-enriched FISH for multiple myeloma as a result of our extensive collaboration with academic and commercial institutions.

We perform both manual and automated processing on formalin-fixed paraffin-embedded (FFPE) solid tumor samples, including breast, lung, bladder, brain cancers and others. Most of the manual processing of FFPEs includes FDA cleared ALK FISH for lung carcinoma and Pathvysion for breast carcinoma.

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